REGULATORY SYSTEMS OF STRUCTURAL-FUNCTIONAL UNITS OF SKIN IN NORM AND PATHOLOGY

V. Bocharov, L. Zubkova, V. Bocharova

Abstract


The subject of the study is the regulatory systems of the structural and functional units of the skin and visible mucous membranes that contact the skin under conditions of physiological activity and pathophysiological changes. The aim of the study was to study molecular, subcellular, cellular, tissue and organ systems regulating the morphological features and functions of the skin. A modern approach to the evaluation of the formation and functioning of structural and functional units of the skin and its significance for the diagnosis, treatment and prevention of diseases associated with their damage by various etiological factors are proposed.

Keywords: regulatory systems of different levels of the skin.

1В. А. Бочаров, доктор медицинских наук, профессор; 1Л. П. Зубкова, доктор медицинских наук, профессор; 2В. В. Бочарова, кандидат медицинских наук. Регуляторные системы структурно-функциональных единиц кожи в норме и патологии / 1Медицинский центр «ORTO-DENT/BIO-DERM», Украина, Одесса; 2Одесский национальный медицинский университет, Украина, Одесса

Предмет исследования – регуляторные системы структурно-функциональных единиц кожи и видимых слизистых, контактирующих с кожей в условиях физиологической деятельности и патофизиологических изменений. Цель исследования – изучить молекулярные, субклеточные, клеточные, тканевые и органные системы, регулирующие морфологические особенности и функции кожи. Предложен современный подход к оценке формирования и функционирования структурно-функциональных единиц кожи и его значения для диагностики, лечения и профилактики заболеваний, связанных с их повреждением различными этиологическими факторами.

Ключевые слова: регуляторные системы различных уровней кожи.


Full Text:

PDF

References


Пальцев М. А. Руководство по нейроиммуноэндокринологии / М. А. Пальцев, И. М. Кветной. – М.: Медицина, 2006. – 384 с.

Основы клинической иммунологии / Э. Чепель, М. Хейни, С. Мисбах, Н. Сновден; пер. с англ. – М.: ГЭОТАР-Медиа, 2008. – 416 с.

Siebenhaar F., Sharov A. A., Sharova T. Y. [et al.] Substance p as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata) // Journal of Investigative Dermatology. – 2007. – Vol. 127(6). – P. 1489-1497.

Кошевенко Ю. Н. Кожа человека. Том 1. Структура, физиология и предназначение функциональных элементов кожного органа человека / Ю. Н. Кошевенко. – М.: Медицина, 2006. – 360 с.

Гистология. 2-е изд., перераб. и доп. / ред. Э. Г. Улумбекова, Ю. А. Челышева. – М.: ГЭОТАР-МЕД, 2002. – 672 с.

Zaba L. C., Fuentes-Duculan J., Eungdamrong N. J. [et al.] Identification of TNF-related apoptosis-inducing ligand and other molecules that distinguish inflammatory from resident dendritic cells in patients with psoriasis // J. Allergy. Clin. Immunol. – 2010. – Vol. 125(6). – P. 1261-1268.

El-Ramly A.Z., Fawzi M.M.T., Mahmoud S.B. et al. Assessment of serum levels of cathelicidin and vitamin D in acne vulgaris // Journal of the Egyptian Women's Dermatologic Society. – 2016. – Vol. 13(2). – P. 99-105.

Furci L., Baldan R. Bianchini V., Trovato A., Ossi C., Cichero, P., Cirillo, D. M. New role human α-defensin 5 in the fight against hypervirulent Clostridium difficile strains // Infection and Immunity. – 2015. – Vol. 83(3). – P. 986-995.

Iwasaki A., Medzhitov R. Control of adaptive immunity by the innate immune system // Nat. Immunol. – 2015. – Vol. 16 (4). – P. 343-353.

Kim S. Y., Hyun M. Y., Go K. C., Zouboulis C. C., Kim B. J. Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway // International Journal of Molecular Medicine. – 2015. – Vol. 35(4). – P. 1042-1050.

Menha A. I., Manal E. H., Hanan H. S. et al. Evaluation of biomarkers of oxidant–antioxidant balance in patients with acne vulgaris // Journal of the Egyptian Women's Dermatologic Society. – 2015. – Vol. 12(2). – P. 136-141.

Orion E. Psychological factors in skin diseases: stress and skin factors and controversies / E. Orion, R. Wolf // Clin. Dermatol. – 2013. – Vol. 31(6). – P. 707-711.

Scudiero O., Nigro E., Cantisani [et al.] Design and activity of a cyclic mini-α-defensin analog: a novel antimicrobial tool // Int. J. Nanomedicine. – 2015. – Vol. 10. – P. 6523-6539.

Simpson R. C. What’s new in acne? An analysis of systematic reviews and clinically significant trials published in 2010-2011 / R. C. Simpson, D. J. Grindlay, H. C. Williams // Clin. Exp. Dermatol. – 2011. – Vol. 36(8). – P. 840-843.

Toll-like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne / Joanne Louise Selway, Tomasz Kurczab, Terence Kealey, Kenneth Langlands // BMC Dermatology. – 2013. – Vol. 13:10 doi:10.1186/1471-5945-13-10.

Wang G. Human Antimicrobial Peptides and proteins // Pharmaceuticals. – 2014. – Vol. 7(5). – P. 545-594.

Zeichner J. A. Inflammatory Acne Treatment: Review of Current and New Topical Therapeutic Options / J. A. Zeichner // J. Drugs Dermatology. – 2016. – Vol. 15 (Suppl. 1). – P. s11-s16.

Zhao X., Wu H., Lu H. [et al.] LAMP: A Database Linking Antimicrobial Peptides // PloS One. – 2013. – Vol. 18(8), N. 6. – P. 1-6.

Zouboulis C. C. Neuroendocrine regulation of sebocytes – a pathogenetic linkbetween stress and acne / C. C. Zouboulis // Exp. Dermatol. – 2004. – Vol. 13 (Suppl. 4). – P. 31-5.

References:

Paltsev M. A., Kvetnoy I. M. (2006). Rukovodstvo po neyroimmunoendokrinologii. Moscow: Medicina. [in Russian].

Chepel` E., Hejni M., Misbah S., Snovden N. (2008). Osnovy klinicheskoj immunologii [Essentials of Clinical Immunology]; per. s angl. Moscow: GEHOTAR-Media. [in Russian].

Siebenhaar F., Sharov A. A. , Sharova T. Y. et al. (2007). Substance p as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata). Journal of Investigative Dermatology, 127(6), 1489-1497. [in English].

Koshevenko Yu. N. (2006). Kozha cheloveka. Tom 1. Struktura, fiziologiya i prednaznachenie funkcional`nyh ehlementov kozhnogo organa cheloveka. Moscow: Medicina. [in Russian].

Ulumbekov Eh. G., Chelyshev Yu. A. (2002). Gistologiya [Histology]; 2-e izd., pererab. i dop. Moscow: GEHOTAR-MED. [in Russian].

Zaba L. C., Fuentes-Duculan J., Eungdamrong N. J. et al. (2010). Identification of TNF-related apoptosis-inducing ligand and other molecules that distinguish inflammatory from resident dendritic cells in patients with psoriasis. J. Allergy. Clin. Immunol., 125(6), 1261-1268. doi: 10.1016/j.jaci.2010.03.018.

El-Ramly A. Z., Fawzi M. M. T., Mahmoud S. B. et al. (2016). Assessment of serum levels of cathelicidin and vitamin D in acne vulgaris. Journal of the Egyptian Women's Dermatologic Society, 13(2), 99-105. [in English].

Furci L., Baldan R. Bianchini V., Trovato A., Ossi C., Cichero, P., Cirillo, D. M. (2015). New role human α-defensin 5 in the fight against hypervirulent Clostridium difficile strains. Infection and Immunity, 83(3), 986-995. doi: 10.1128/IAI.02955-14.

Iwasaki A., Medzhitov R. (2015). Control of adaptive immunity by the innate immune system. Nat. Immunol., 16,(4), 343-353. doi: 10.1038/ni.3123.

Kim S. Y., Hyun M. Y., Go K. C., Zouboulis C. C., Kim B. J. (2015). Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway. International Journal of Molecular Medicine, 35(4), 1042-1050. doi: 10.3892/ijmm.2015.2098.

Menha A. I., Manal E. H., Hanan H. S. et al. (2015). Evaluation of biomarkers of oxidant–antioxidant balance in patients with acne vulgaris. Journal of the Egyptian Women's Dermatologic Society, 12(2), 136-141. [in English].

Orion E., Wolf R. (2013). Psychological factors in skin diseases: stress and skin factors and controversies. Clin. Dermatol., 31(6), 707-711. doi: 10.1016/j.clindermatol.2013.05.006.

Scudiero O., Nigro E. Cantisani et al. (2015). Design and activity of a cyclic mini-α-defensin analog: a novel antimicrobial tool. Int. J. Nanomedicine, 10, 6523-6539. [in English].

Simpson R. C., Grindlay D. J., Williams H. C. (2011). What’s new in acne? An analysis of systematic reviews and clinically significant trials published in 2010-2011. Clin. Exp. Dermatol., 36(8), 840-843. [in English].

Joanne Louise Selway, Tomasz Kurczab, Terence Kealey, Kenneth Langlands (2013). Toll-like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne. BMC Dermatology, 13, 10. doi:10.1186/1471-5945-13-10.

Wang G. (2014). Human Antimicrobial Peptides and proteins. Pharmaceuticals, 7(5), 545-594. doi:10.3390/ph7050545pharmaceuticals.

Zeichner J. A. (2016). Inflammatory Acne Treatment: Review of Current and New Topical Therapeutic Options. J. Drugs Dermatology, 15(1), s11-s16. [in English].

Zhao X., Wu H., Lu H. et al. (2013). LAMP: A Database Linking Antimicrobial Peptides. PloS One, 18;8(6), 1-6. doi: 10.1371/journal.pone.0066557.

Zouboulis C. C. (2004). Neuroendocrine regulation of sebocytes – a pathogenetic linkbetween stress and acne. Exp. Dermatol., 13(Suppl. 4), 31-5. [in English].




DOI: https://doi.org/10.26886/10.26886/2523-6946.1(1)2017.1

Refbacks

  • There are currently no refbacks.


Ліцензія Creative CommonsThis work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 International.